About

CARB scientists are leading in the development and application of novel NMR measurement methods, models, and databases to gain new insights into macromolecular structure, dynamics and interactions.

Detailed knowledge of the structure and dynamics of macromolecules is critical for a complete understanding of biochemical reaction mechanisms and molecular recognition processes. Such an understanding can impact biotechnology and bioengineering efforts in the areas of pharmaceutical development and biomaterials design. Several research programs, involving nuclear magnetic resonance (NMR) spectroscopy, are under way at CARB in which scientists are developing and utilizing state-of-the art measurement methods, models and databases to study macromolecular structure, dynamics and interactions. Research projects include investigations into the structure and dynamics of RNA and RNA-protein complexes involved in gene regulation and retroviral infection, proteins involved in Ca+2 -dependent signal transduction, G-protein coupled receptors, and structural genomics. Studies are also underway which utilize NMR measurements to study macromolecular folding and stability.