Research Description

Research Specialty: Proteomics of Aging

 

The lab is focused on the mass spectrometry-based quantitative techniques to assess age-related proteomic changes in brain and retina.

 

Current scientific interests include:

 

(1) Multiple Reaction Monitoring Measurements for proteins involved in the generation, disposal, and function of oxysterols in the senescent retinal pigmented epithelium.

 

(2) Hydrogen-Deuterium Exchange Mass Spectrometry for analysis of structural changes in cytochrome P450s during interactions with substrates, inhibitors, and protein partners.

 

(3) Quantitative protein profiling of age-related diseases of human brain and retina.